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May 26, 2026Journal of Natural Products

Discovery of Rearranged Steroids from Cultures of Penicillium soli as Inhibitors of Idiopathic Pulmonary Fibrosis

Ming Chen Xueqi Lan Xue Gong Xinye Huang Dechao Meng W J Sun Chao Zhao Changxing Qi Y C Zhang

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Key Points

This research aims to identify steroids from Penicillium soli that inhibit idiopathic pulmonary fibrosis (IPF).
Tested compounds in NIH/3T3 cells for antifibrotic activity
Assessed effects in bleomycin-induced IPF mice models
Compounds suppressed TGF-β1-driven fibroblast activation and extracellular matrix production
Alleviated pathological changes in bleomycin-induced IPF mice, indicating potential therapeutic benefits

Implication

Study discovers rearranged steroids that inhibit fibrosis in mice, suggesting new therapeutic options.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a192cb4fab5b468c4415834 https://doi.org/10.1021/acs.jnatprod.6c00334

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