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May 29, 2026ACS OmegaOpen Access

Repurposing Fingolimod as an Antibacterial and Antibiofilm Agent against Carbapenem-Resistant Acinetobacter baumannii

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Authors

HJHye-Won JinJBJi-Hui BaeHYHyung‐Sun Youn

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Overview

Randomized trial evaluated fingolimod's antibacterial effects against carbapenem-resistant Acinetobacter baumannii, suggesting a new treatment avenue.

Key Points

  • This study aims to assess the antibacterial and antibiofilm properties of fingolimod against carbapenem-resistant Acinetobacter baumannii.
  • Determined minimum inhibitory concentration of fingolimod against clinical isolates.
  • Evaluated biofilm inhibition and eradication using specific concentration assays.
  • Analyzed gene expression related to carbapenemase and biofilm formation using quantitative reverse transcription PCR.
  • Fingolimod inhibited bacterial growth by up to 98% at 4–8 μg/mL.
  • Significant reduction of biofilm formation in a concentration-dependent manner.
  • Fingolimod treatment downregulated all target genes associated with resistance and biofilm formation.

Cite This Study

Jin et al. (2026) studied this question.

synapsesocial.com/papers/6a192cb4fab5b468c44158a3https://doi.org/10.1021/acsomega.5c12513
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