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May 29, 2026Clinical Lung CancerOpen Access

Complete spontaneous regression of lung adenocarcinoma with no residual malignancy after surgical resection: a case report

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Case report shows spontaneous regression of lung adenocarcinoma in a smoker, suggesting immune involvement.

To report a rare case of complete spontaneous regression of lung adenocarcinoma after surgical removal.
Patient was a 60-year-old male with a 1.9 cm lung mass and high PD-L1 expression.
PET/CT showed no metastases; EBUS-guided needle aspiration confirmed poorly differentiated adenocarcinoma.
Post-biopsy, tumor size reduced to 0.8 cm prior to surgical resection.
Pathological examination revealed no residual malignancy in the resected lobe.
Only fibrotic tissue with chronic inflammation was found, indicating spontaneous regression.
High PD-L1 levels and temporal connection with diagnostic procedures suggest an immune-mediated process.

Näslund et al. (2026) studied this question.

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