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May 29, 2026Journal of Clinical Oncology

Durable treatment-free remission in CML beyond clinical trials: Lessons from a large single-center real-world experience.

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Authors

SGSadashivudu GundetiNizam's Institute of Medical SciencesRCRachana ChennamaneniNizam's Institute of Medical SciencesMKMeher Lakshmi KonatamNizam's Institute of Medical Sciences

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Implication

Retrospective analysis demonstrates high rates of treatment-free remission in chronic myeloid leukemia, suggesting flexible monitoring strategies.

Key Points

  • This research aims to analyze the effectiveness of treatment-free remission in chronic myeloid leukemia outside of clinical trial settings.
  • Conducted a retrospective single-center analysis of chronic-phase CML patients who discontinued TKI therapy.
  • Collected data on demographics, deep molecular response duration, cumulative TKI exposure, and relapse monitoring.
  • Evaluated relapse-free survival using Kaplan-Meier methods.
  • 81.8% of patients maintained sustained treatment-free remission at a median follow-up of 40 months.
  • TFR rates were 92% at 6 months, 87% at 12 months, and 82% at 24 months.
  • No significant differences in relapse risk based on DMR duration, cumulative TKI exposure, or monitoring adherence.

Cite This Study

Gundeti et al. (2026) studied this question.

synapsesocial.com/papers/6a192d2dfab5b468c4415f93https://doi.org/10.1200/jco.2026.44.16_suppl.6582
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Also Consider

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  1. 1Predictors of successful tirosine kinase inhibitor discontinuation in chronic myeloid leukemia: Long-term, real-world evidence on the role of faster molecular decline and duration of response2025
  2. 2Real-World Evidence-Based Study on Treatment-Free Remission in Chronic Myeloid Leukemia2026
  3. 3Predictive factors for successful treatment-free remission in patients with chronic myeloid leukemia: A pooled analysis2025
  4. 4Molecular remission after tyrosine kinase inhibitor cessation in chronic myeloid leukemia (CML): A systematic review and meta-analysis.2026
  5. 5TKI Use and Treatment-Free Remission in Chronic Myeloid Leukemia: Evidence from a Regional Cohort Study in the Canary Islands2025