What question did this study set out to answer?

This study aims to identify risk factors for synchronous and metachronous second primary cancer among breast cancer survivors.

May 29, 2026npj Breast CancerOpen Access

Risk factors for second primary cancer in patients who survive breast cancer

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This study aims to identify risk factors for synchronous and metachronous second primary cancer among breast cancer survivors.
Population-based cohort study using data from the South Korean Cancer Public Library Database.
Included female patients diagnosed with primary breast cancer from 2012 to 2019.
Used Cox proportional hazards models to identify risk factors and examined causes of death.
497 women developed synchronous SPC and 812 women developed metachronous SPC.
Age ≥70 years was associated with higher risk for both SPC types (HR 3.58 for sSPC, HR 3.18 for mSPC; both P < 0.001).
Fasting blood sugar ≥140 mg/dL was linked with sSPC (HR 1.61; P = 0.02), but not mSPC.

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Implication

Population-based cohort study identifies risk factors for second primary cancer in breast cancer survivors, suggesting tailored survivorship strategies for high-risk groups.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6a192d65fab5b468c441636f https://doi.org/10.1038/s41523-026-00975-4

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Implication

Population-based cohort study identifies risk factors for second primary cancer in breast cancer survivors, suggesting tailored survivorship strategies for high-risk groups.

Risk factors for second primary cancer in patients who survive breast cancer

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Discussion

Implication

Cite This Study

Risk factors for second primary cancer in patients who survive breast cancer

Key Points

Discussion

Implication

Cite This Study

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