Acute otitis media in children: molecular genetics approach (rs1061581), clinical and micro-social predictors (single-center cross-sectional case-control study)

BACKGROUND: most frequent ENT diagnosis in early childhood. OBJECTIVE: The aim of the study was to evaluate the clinical, anamnestic and micro-social predictors of AOM in children and its association with heat-shock protein gene (HSP70-2, rs1061581) polymorphism. MATERIAL AND METHODS: A total of 95 children with AOM (7-18 years old) participated in the study. HSP70-2 (rs1061581) gene genotyping was performed by qPCR method. Risk factors were analyzed. RESULTS: = 0.001). CONCLUSION AND SIGNIFICANCE: Clinical and social predictors affect the severity of AOM in children depending on age. A-allele (rs1061581) associates with a more severe AOM course in children.