Key result
Children with MRSA acute hematogenous osteomyelitis demonstrated over-expression of innate immunity and under-expression of adaptive immunity genes, with STAT4 downregulation showing the strongest correlation to clinical severity of illness (R2 = -0.83).
Population
12 previously healthy children with acute hematogenous osteomyelitis due to Methicillin-resistant…
Comparison
Whole blood gene expression microarray analysis vs Healthy age, ethnicity, and gender-matched…
Design
Case-control
Follow-up
Early hospitalization
Authors
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Gene expression signatures correlate with severity in pediatric MRSA osteomyelitis; hypothesis-generating for risk stratification pending validation.
Case-Control (n=19)
No
Effect estimate: R2 = -0.83
p-value: p=<0.05
Specific gene expression patterns, notably STAT4 downregulation and RETN upregulation, correlate with clinical severity in children with MRSA acute hematogenous osteomyelitis.
Gaviria-Agudelo et al. (2014) conducted a case-control in Acute hematogenous osteomyelitis (AHO) caused by Methicillin-Resistant Staphylococcus aureus (MRSA) (n=19). Acute hematogenous osteomyelitis caused by MRSA vs. Healthy matched controls was evaluated on Correlation of quantitative gene expression with clinical severity of illness score (R2 = -0.83, p=<0.05). Children with MRSA acute hematogenous osteomyelitis demonstrated over-expression of innate immunity and under-expression of adaptive immunity genes, with STAT4 downregulation showing the strongest correlation to clinical severity of illness (R2 = -0.83).
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