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May 29, 2026Journal of Clinical MedicineOpen Access

Gut Microbiota, Metabolic Markers, and Systemic Inflammation in Young Women with Self-Reported Rosacea: An Exploratory Cross-Sectional Study

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Authors

PPPaola PavačićUniversity of ZagrebEKEmanuela KrpanUniversity of ZagrebKZKarlo ZemanUniversity of Zagreb

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Implication

Exploratory cross-sectional study examines gut microbiota and inflammation in young women with rosacea, indicating potential links but requiring further validation.

Key Points

  • This study explores connections between gut microbiota, metabolic markers, and inflammation in young women with self-reported rosacea.
  • Cohort of Croatian women (N=300, ages 30-35) with 19 reporting rosacea; controls matched (n=281).
  • Assessment included questionnaires, blood parameters, and fecal 16S rRNA sequencing (QIIME2).
  • Statistical analysis used Mann–Whitney U tests with Benjamini–Hochberg FDR correction.
  • Rosacea associated with higher BMI (p = 0.037) and poorer sleep quality (p = 0.038).
  • Fecal analysis identified nominally significant taxa; Bifidobacterium was depleted (p = 0.007).
  • Random Forest classifier had LOOCV AUC = 0.785 for predicting using five genera and HOMA-B.

Cite This Study

Pavačić et al. (2026) studied this question.

synapsesocial.com/papers/6a192d65fab5b468c441644ehttps://doi.org/10.3390/jcm15114130
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