Differential IDH1 Immunohistochemical Expression Across the Pathologically Stratified Spectrum of Intraepithelial and Invasive Laryngeal Squamous Cell Lesions.

Background p = 0.026, 0.025) and histopathological progression and grade (p = 0.033, 0.036). Two-year DFS and OS were 81.5% and 69%, respectively, with no significant association between survival outcomes and IDH1 H-score (p = 0.851, 0.225). Conclusion: According to our findings, increased IDH1 expression may be associated with features of aggressive tumor behavior and could hold clinical significance in laryngeal squamous cell lesions, potentially serving as a future therapeutic target.