What question did this study set out to answer?

This research aims to evaluate the effectiveness of sulfonamide derivatives in inhibiting 5'-nucleotidases activity.

May 29, 2026

Synthesis, characterization, in-silico , and in-vitro evaluation of 4-amino- N -(4-aminophenyl)benzene sulfonamide derivatives against Naja oxiana 5’-nucleotidases (5’-NT) enzyme

Key Points

This research aims to evaluate the effectiveness of sulfonamide derivatives in inhibiting 5'-nucleotidases activity.
Synthesis and characterization of HAS-series derivatives
In-silico evaluation of binding energies against the enzyme
In-vitro testing for 5'-NT activity inhibition
Derivatives exhibited higher binding energies than standard antidotes (-8.1 kcal/mol, -7.5 kcal/mol)
Demonstrated favorable pharmacokinetic profiles with high bioavailability
Potential analogues could be effective against adenosine-induced toxicities

Abstract

AIM: -(4-aminophenyl)benzene sulfonamide derivatives (HAS-series). METHODS: for their potentials to halt 5'-NT activity. RESULTS: > 0.5) when compared with standard antidote having low binding energies (-8.1 kcal/mol and -7.5 kcal/mol) against the target. Favorable pharmacokinetic safety profile was observed characterized with high absorption, compliance in Lipinski's rule, low penetration power to the brain with effective bioavailability. CONCLUSIONS: Based on the data compiled, both potential analogues could be promising target against 5'-NT to cope with adenosine-induced toxicities. However, detailed study is inevitable to access their lipophilicity and toxicity profile prior safely use in the victims.

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