Synthesis, characterization, in-silico , and in-vitro evaluation of 4-amino- N -(4-aminophenyl)benzene sulfonamide derivatives against Naja oxiana 5’-nucleotidases (5’-NT) enzyme

AIM: -(4-aminophenyl)benzene sulfonamide derivatives (HAS-series). METHODS: for their potentials to halt 5'-NT activity. RESULTS: > 0.5) when compared with standard antidote having low binding energies (-8.1 kcal/mol and -7.5 kcal/mol) against the target. Favorable pharmacokinetic safety profile was observed characterized with high absorption, compliance in Lipinski's rule, low penetration power to the brain with effective bioavailability. CONCLUSIONS: Based on the data compiled, both potential analogues could be promising target against 5'-NT to cope with adenosine-induced toxicities. However, detailed study is inevitable to access their lipophilicity and toxicity profile prior safely use in the victims.