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This case aims to illustrate the complexities of diagnosing and treating statin-induced necrotizing autoimmune myopathy in an elderly patient.

May 29, 2026Clinical Case ReportsOpen Access

Diagnostic and Therapeutic Challenges in Statin‐Induced Necrotizing Autoimmune Myopathy in an Elderly Patient: A Rare Case Report

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Case report details persistent muscle weakness in an elderly patient, highlighting diagnostic and treatment difficulties.

This case aims to illustrate the complexities of diagnosing and treating statin-induced necrotizing autoimmune myopathy in an elderly patient.
Described the clinical history and symptoms of a 78-year-old woman on atorvastatin.
Conducted laboratory evaluations including creatine kinase levels and anti-HMGCR antibody testing.
Utilized MRI to confirm the diagnosis of myositis.
The patient exhibited significantly elevated creatine kinase levels and positive anti-HMGCR antibodies.
Despite discontinuing statins and initiating immunosuppressive treatment, muscle weakness persisted.
The patient was bedbound at long-term follow-up, indicating the gravity of the condition.

Shrestha et al. (2026) studied this question.

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