Diagnostic and Prognostic Values of Eosinopenia, Neutrophil to Lymphocyte Ratio, Lactate and Lactate Clearance in Neonatal Sepsis. A Prospective-Cohort Study
Prospective cohort study assesses diagnostic and prognostic values of eosinopenia and lactate in neonatal sepsis, indicating critical insights for clinicians.
Key Points
This study aims to evaluate eosinopenia, neutrophil to lymphocyte ratio, and lactate levels as diagnostic and prognostic biomarkers in neonatal sepsis.
Prospective cohort study in a tertiary neonatal intensive care unit including 200 neonates.
Neonates classified into septic (n=100) and control (n=100) groups based on clinical and laboratory criteria.
Diagnostic metrics assessed included eosinophil percentage, NLR, and lactate levels with ROC curve analysis.
Eosinopenia showed the highest diagnostic accuracy with 100% sensitivity and 99% specificity (median 0.5% vs. 3.5%, p<0.001).
NLR was elevated in the septic group (median 3.2 vs. 1.3, p<0.001) but had limited diagnostic value (sensitivity 64%, specificity 100%).
Initial lactate levels were significantly higher in septic neonates (20.3 ± 2.6 vs. 11 ± 3.6 mmol/L, p<0.001) and linked to poor outcomes, showing 87.76% sensitivity for mortality.