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This review focuses on the essential roles of amino acids and protein in managing hypercatabolic states and their impacts on clinical outcomes.

May 29, 2026NutrientsOpen Access

Amino Acids as Metabokines in Hypercatabolic States: Rethinking Nutritional Protein-Based Strategies Beyond Caloric Support

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Narrative review examines amino acids and protein roles in metabolic regulation for improved outcomes.

This review focuses on the essential roles of amino acids and protein in managing hypercatabolic states and their impacts on clinical outcomes.
Narrative review of interactions between energy intake, dietary protein, and amino acids in various diseases.
Discusses pathophysiological features of hypercatabolic states and their implications for nutrition.
Explores the signaling roles of essential amino acids in metabolic regulation.
High protein intake alone does not sustain anabolism without adequate energy, indicating a need for balanced energy and amino acids.
Targeted EAA supplementation can help mitigate anabolic resistance in hypercatabolic conditions.
Protein quality and balanced availability of all essential amino acids are more crucial for lean mass preservation than total caloric intake.

Corsetti et al. (2026) studied this question.

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