What question did this study set out to answer?

This study aims to quantify the incidence and severity of immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors (ICIs) and identify predictors of their development.

May 29, 2026Journal of Clinical Oncology

Immune checkpoint inhibitor (ICI) toxicity in a large prospective cohort of patients with solid tumors: The I-CHECKIT study (SWOG S2013).

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This study aims to quantify the incidence and severity of immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors (ICIs) and identify predictors of their development.
Conducted a prospective cohort study with 2084 enrolled patients planning to receive ICI therapy.
Analyzed outcomes from patients receiving either single drug or combination ICI therapy over one year.
IraE events were centrally reviewed, and grade ≥3 non-hematologic irAEs were assessed per CTCAE v5.
Among 2020 eligible patients, 13.3% experienced grade ≥3 non-hematologic irAEs within the first year.
Incidence of irAEs was higher in combination therapy patients (27.4%) compared to single drug patients (10.5%, Chi-square p<.001).
The most common irAEs were hepatitis (21.2%), gastrointestinal disorders (19.3%), and respiratory issues (10.0%).

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Implication

Prospective trial assesses irAE incidence and severity in patients receiving ICI therapy, suggesting important predictors.

Cite This Study

Gunturu et al. (2026) studied this question.

synapsesocial.com/papers/6a192de6fab5b468c4416d7b https://doi.org/10.1200/jco.2026.44.16_suppl.2640

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Immune checkpoint inhibitor (ICI) toxicity in a large prospective cohort of patients with solid tumors: The I-CHECKIT study (SWOG S2013).

Key Points

Discussion

Implication

Cite This Study

Immune checkpoint inhibitor (ICI) toxicity in a large prospective cohort of patients with solid tumors: The I-CHECKIT study (SWOG S2013).

Key Points

Discussion

Implication

Cite This Study

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