What question did this study set out to answer?

This review aims to evaluate the prognostic significance of TP53 mutations on survival outcomes in adult patients with acute myeloid leukemia.

May 29, 2026

Prognosis of Acute Myeloid Leukemia Based on TP53 Mutation Among Adult Patients: A Systematic Review and Meta-Analysis.

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Systematic review assesses TP53 mutations' influence on survival in adult AML, indicating significant risk implications.

This review aims to evaluate the prognostic significance of TP53 mutations on survival outcomes in adult patients with acute myeloid leukemia.
Performed a systematic review following PRISMA guidelines
Searched databases including PubMed, Scopus, and Web of Science for relevant studies
Calculated pooled hazard ratios for overall survival and relapse-free survival using a random-effects model.
Pooled HR for overall survival in TP53-mutated patients was 2.22 (95% CI: 2.08-2.37) compared to wild-type patients.
Pooled HR for relapse-free survival was 2.25 (95% CI: 1.98-2.56), indicating a higher relapse risk.
Moderate heterogeneity observed for overall survival (I²=71%, p<0.01) and low for relapse-free survival (I²=0%, p=0.58).

Ameli et al. (2026) studied this question.

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