What does this research mean for the field?

Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates corneal repair by promoting corneal epithelial proliferation through the PAC1 receptor and NR4A1 signaling pathway. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to clarify how PACAP promotes the regeneration of corneal epithelial cells.

May 29, 2026Scientific ReportsOpen Access

Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes regeneration of corneal epithelial cells possibly via the NR4A1 signaling pathway

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This research aims to clarify how PACAP promotes the regeneration of corneal epithelial cells.
Used a mouse corneal wound-injury model and human corneal epithelial cell cultures
Administered PACAP eye drops and analyzed corneal healing
Conducted DNA whole-genome microarray analysis to identify key signaling pathways
PACAP significantly reduced the injured corneal area in mice (12 hours post-injury) with effect abolished by PACAP receptor antagonist
Corneal healing was delayed in PACAP knockout and PAC1-R knockout mice
PACAP promotes epithelial proliferation via NR4A1, as indicated by DNA microarray analysis and effects of THPN on proliferation.

Discussion

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Implication

Randomized trial demonstrates PACAP enhances corneal repair in mice, suggesting therapeutic potential for corneal injuries.

Cite This Study

Yamashita et al. (2026) studied this question.

synapsesocial.com/papers/6a192df7fab5b468c4416fc5 https://doi.org/10.1038/s41598-026-54554-5

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Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes regeneration of corneal epithelial cells possibly via the NR4A1 signaling pathway

Key Points

Discussion

Implication

Cite This Study

Pituitary adenylate cyclase-activating polypeptide (PACAP) promotes regeneration of corneal epithelial cells possibly via the NR4A1 signaling pathway

Key Points

Discussion

Implication

Cite This Study

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