What question did this study set out to answer?

This research investigates the safety and efficacy of revumenib as maintenance therapy in AML patients following allogeneic stem cell transplantation.

May 29, 2026Journal of Clinical Oncology

Revumenib as maintenance for AML following allogeneic stem cell transplantation.

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Authors

HGHannah GoulartThe University of Texas MD Anderson Cancer Center OOOlayinka OkelejiThe University of Texas MD Anderson Cancer Center CDCourtney D. DiNardoThe University of Texas MD Anderson Cancer Center

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Randomized trial examines overall survival and relapse rates following revumenib maintenance in AML patients, suggesting favorable outcomes.

Key Points

This research investigates the safety and efficacy of revumenib as maintenance therapy in AML patients following allogeneic stem cell transplantation.
21 patients (11 adults, 10 pediatric) participated; 62% female.
Patients were on revumenib maintenance after response to treatment pre-SCT, resuming at pre-SCT doses.
Follow-up median duration was 18.2 months, assessing overall survival and event-free survival outcomes.
1- and 2-year overall survival rates were 89%; event-free survival rates were 84% and 73%, respectively.
The 1-year cumulative incidence of relapse was 11%, while death occurred in 5% of cases.
29% of patients remained on revumenib by last follow-up, with thrombocytopenia being the most common adverse event.

Cite This Study

Goulart et al. (2026) studied this question.

synapsesocial.com/papers/6a192df7fab5b468c4417088 https://doi.org/10.1200/jco.2026.44.16_suppl.6505

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Implication

Randomized trial examines overall survival and relapse rates following revumenib maintenance in AML patients, suggesting favorable outcomes.

Revumenib as maintenance for AML following allogeneic stem cell transplantation.

Discussion

Member takes

Implication

Key Points

Cite This Study

Revumenib as maintenance for AML following allogeneic stem cell transplantation.

Discussion

Member takes

Implication

Key Points

Cite This Study

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