Developing harmonized tumor microenvironment subtypes for patient stratification in clinical trials.

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The aim is to create a harmonized classification of tumor microenvironments for better patient stratification in clinical trials.
Developed a harmonized TME classification using agglomerative clustering of gene signature scores and pathway activities.
Validated on TCGA and internal pan-cancer cohorts (N=12,548) with high reproducibility and on 29,875 solid cancer samples using K-Nearest Neighbors.
Applied adjusted Cox models for survival and logistic regressions for response assessments.
HTME classification revealed significant patient stratification across three biological axes: immune response vs. tumor cell activity, fibrosis vs. antigen presentation, proliferation vs. vascularization.
HTME effectively distinguished patient responses to therapies, achieving statistically significant p-values (p≤0.05) across various cancer types.

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Randomized trial develops harmonized tumor microenvironment subtypes for patient stratification, suggesting improved outcomes in immunotherapy.

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Lukashevich et al. (2026) studied this question.

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