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March 4, 2024Cancer Research

Abstract B073: A spatially resolved single-cell tumor microenvironment of clinicomolecular subtypes of high-grade serous ovarian cancer

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Authors

FPFernando Pérez‐VillatoroLWLilian van WagensveldASAleksandra Shabanova

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Overview

Analysis reveals distinct tumor microenvironments in high-grade serous ovarian cancer, suggesting biomarkers for precision oncology.

Key Points

  • High immune cell infiltration correlates with prolonged survival in optimally debulked high-grade serous ovarian cancer patients.
  • Analysis identified 13 distinct recurrent cellular neighborhoods, showing significant differences between HRD and CCNE1 samples.
  • Using machine learning, we detected MHC-I expression patterns unique to HRD-positive tumors across 1000 tumor cores analyzed with cyclic immunofluorescence imaging data and software tools for single-cell analysis. The integration of multi-omics data highlights the impact of the tumor microenvironment on clinical outcomes in ovarian cancer.

Cite This Study

Pérez‐Villatoro et al. (2024) studied this question.

synapsesocial.com/papers/68e75dc8b6db6435876d49bbhttps://doi.org/10.1158/1538-7445.ovarian23-b073
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 801: Genomic and spatial single-cell profiling reveals BRCA-linked tumor microenvironment signatures in high-grade serous ovarian carcinoma.2026
  2. 2Abstract 5479: Spatially resolved molecular features in the tumor-immune microenvironment of germline BRCA1/2 mutated versus BRCA wild type high grade serous ovarian cancers2024
  3. 3Abstract B077: Spatial patterns of immune cell states are associated with poor response to neoadjuvant chemotherapy in high-grade serous ovarian cancer2024
  4. 4Abstract B083: Single-cell and spatial transcriptomic characterization of treatment resistance and immune dynamics in high-grade serous ovarian cancer2024
  5. 5Abstract B061: Multiparametric single-cell characterization of the immune tumor microenvironment in ovarian carcinomas2024