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March 4, 2024Cancer Research

Abstract B083: Single-cell and spatial transcriptomic characterization of treatment resistance and immune dynamics in high-grade serous ovarian cancer

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Authors

KIKathleen J. ImbachJosep Carreras Leukaemia Research InstituteVNVikram NaganathanJosep Carreras Leukaemia Research InstituteABArola Fortian BernabeuInstitut d'Investigació en Ciències de la Salut Germans Trias i Pujol

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Implication

Pilot study characterizes treatment resistance mechanisms in high-grade serous ovarian cancer, suggesting new therapy targets.

Key Points

  • Treatment resistance is linked to upregulated vesicle-related genes, indicating the influence of extracellular vesicles on chemotherapy outcomes.
  • Analysis of 3 chemotherapy-sensitive and 2 resistant samples reveals key immune dynamics connected to gene expression differences.
  • Utilizing single-cell and spatial transcriptomics, we identified immune-enriched spatial spots correlated with treatment response in ovarian cancer samples during chemotherapy assessments and survivorship follow-ups.  This work emphasizes potential molecular targets for precision medicine, especially involving extracellular communication pathways, which could enhance treatment efficacy and patient outcomes.

Cite This Study

Imbach et al. (2024) studied this question.

synapsesocial.com/papers/68e75dd0b6db6435876d4a53https://doi.org/10.1158/1538-7445.ovarian23-b083
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A003: Mapping the tumor microenvironment: Spatial Transcriptomic insights into ovarian cancer progression and resistance2025 · 1 citations
  2. 2Abstract 5491: Mapping ovarian cancer spatial organization uncovers immune evasion drivers at the genetic, cellular, and tissue level2024
  3. 3Abstract B073: A spatially resolved single-cell tumor microenvironment of clinicomolecular subtypes of high-grade serous ovarian cancer2024
  4. 4Abstract 5479: Spatially resolved molecular features in the tumor-immune microenvironment of germline BRCA1/2 mutated versus BRCA wild type high grade serous ovarian cancers2024
  5. 5Abstract 801: Genomic and spatial single-cell profiling reveals BRCA-linked tumor microenvironment signatures in high-grade serous ovarian carcinoma.2026