What question did this study set out to answer?

The aim is to validate dose calculations for 125I-seeds used in brachytherapy for intraocular tumors.

May 29, 2026Acta OncologicaOpen Access

Validation of absolute dose calculation of a single 125I-seed for ophthalmic brachytherapy within distance range 1–15 mm using a diode detector

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Randomized trial evaluates the dose calculations of 125I-seeds in ocular treatment, suggesting enhanced accuracy for clinical use.

The aim is to validate dose calculations for 125I-seeds used in brachytherapy for intraocular tumors.
Measured dose profiles of I25.S16 seed using a diode detector in a water phantom.
Applied AAPM TG-43 formalism for dose calculation adjustments.
Evaluated the effect of gold backing on dose measurements.
Achieved 97% pass rate in 1D/3D gamma comparisons with criteria 0.3 mm/3%.
Results showed differences in accuracy between gold-to-water ratio corrections and direct measurements.
Diode dosimetry corrections proved useful for accuracy in clinical dose calculations.

Rintala et al. (2026) studied this question.

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