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This review evaluates functional assays of meibomian glands for use in dry eye treatment trial assessments.

Meibomian Gland Outcome Measures in Dry Eye Treatment Trials

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Review examines meibomian gland assays paving the way for standardized outcomes in dry eye trials.

This review evaluates functional assays of meibomian glands for use in dry eye treatment trial assessments.
Conducted an electronic search of MEDLINE for randomized controlled trials between 1995 and 2025.
Included studies reporting outcomes related to meibum secretion and expressibility.
Performed a retrospective chart review of meibum grading data for correlation analysis.
98 studies were analyzed, with the Bron grading system being the most prevalent (n = 48).
High correlation found between meibum opacity and viscosity (Pearson’s r = 0.904, p < 0.001, 95% CI 0.849–0.940).
The modified MGD Workshop grading system is recommended as a core outcome parameter for trials.

Ansari et al. (2026) studied this question.

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