Key result
A higher Type 2 diabetes genetic risk score increased all-cause mortality risk over 17 years (OR 1.04 per risk allele; 95% CI 1.00-1.07; P=0.05), especially among obese non-Hispanic whites.
Why the study?
Does a higher Type 2 diabetes genetic risk score predict all-cause mortality in a multiethnic US population?
Population
6,501 participants from the Third National Health and Nutrition Examination Survey, including 2,528…
Comparison
Higher Type 2 diabetes genetic risk score based… vs Lower Type 2 diabetes genetic risk score
Design
Cohort
Follow-up
17 years
Authors
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Does not support incorporating T2D GRS into mortality risk assessment; leaves open validation and incremental value in diverse cohorts.
Observational (n=6,501)
Yes
Does a higher Type 2 diabetes genetic risk score predict all-cause mortality in a multiethnic US population?
Effect estimate: OR 1.04 (95% CI 1.00-1.07)
p-value: p=0.05
A higher Type 2 diabetes genetic risk score is associated with increased all-cause mortality in the U.S., particularly among obese non-Hispanic white individuals.
Leong et al. (2016) conducted an observational in Type 2 diabetes genetic predisposition (n=6,501). Type 2 diabetes genetic risk score (GRS) was evaluated on All-cause mortality (OR 1.04, 95% CI 1.00-1.07, p=0.05). A higher Type 2 diabetes genetic risk score increased all-cause mortality risk over 17 years (OR 1.04 per risk allele; 95% CI 1.00-1.07; P=0.05), especially among obese non-Hispanic whites.
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