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The research aims to establish a method for quantifying mRNA in intact lipid nanoparticles using Deep-UV resonance Raman spectroscopy.

Deep-UV Resonance Raman Spectroscopy Enables Direct Quantification of mRNA in Intact Lipid Nanoparticle Formulations

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The research aims to establish a method for quantifying mRNA in intact lipid nanoparticles using Deep-UV resonance Raman spectroscopy.
Utilized Deep-UV resonance Raman spectroscopy for rapid and label-free quantification of mRNA.
Applied a multipixel signal-to-noise ratio strategy to enhance detection capabilities.
Ensured minimal interference from lipids and water for accurate readings.
Successfully quantified adenine and guanine signatures in mRNA formulations.
Provided calibrated concentration estimates across various buffers and formulations.
Demonstrated high-throughput capabilities suitable for manufacturing and quality control.

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Randomized trial demonstrates direct quantification of mRNA in lipid nanoparticles, highlighting improved manufacturing efficiency.

Sullivan et al. (2026) studied this question.

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