Cardioversion improved peak workload (+18% vs +7%) and peak VO2 (+17% vs +12%) more in lone atrial fibrillation than in AF with hypertension, and was ineffective in AF with diabetes.
Observational (n=80)
Does cardioversion improve endothelial function and exercise performance in patients with atrial fibrillation associated with hypertension or diabetes compared to lone atrial fibrillation?
The benefits of cardioversion on exercise performance and endothelial function in atrial fibrillation are attenuated by concurrent hypertension and abolished by diabetes, likely due to underlying oxidative injury.
Endothelial dysfunction and underperfusion of exercising muscle contribute to exercise intolerance, hyperventilation, and breathlessness in atrial fibrillation (AF). Cardioversion (CV) improves endothelial function and exercise performance. We examined whether CV is equally beneficial in diabetes and hypertension, diseases that cause endothelial dysfunction and are often associated with AF. Cardiopulmonary exercise and pulmonary and endothelial (brachial artery flow-mediated dilation) function were tested before and after CV in patients with AF alone (n = 18, group 1) or AF with hypertension (n = 19, group 2) or diabetes (n = 19, group 3). Compared with group 1, peak exercise workload, O2 consumption (Vo2), O2 pulse, aerobic efficiency (Delta Vo2/Delta WR), and ratio of brachial diameter changes to flow changes (Delta D/Delta F) were reduced in group 2 and, to a greater extent, in group 3; exercise ventilation efficiency (Ve/Vco2 slope) and dead space-to-tidal volume ratio (Vd/Vt) were similar among groups. CV had less effect on peak workload (+7% vs. +18%), peak Vo2 (+12% vs. +17%), O2 pulse (+33% vs. +50%), Delta Vo2/Delta WR (+7% vs. +12%), Ve/Vco2 slope (-6% vs. -12%), Delta D/Delta F (+7% vs. +10%), and breathlessness (Borg scale) in group 2 than in group 1 and was ineffective in group 3. The antioxidant vitamin C, tested in eight additional patients in each cohort, improved flow-mediated dilation in groups 1 and 2 before, but not after, CV and was ineffective in group 3, suggesting that the oxidative injury is least in lone AF, greater in hypertension with AF, and greater still in diabetes with AF. Comorbidities that impair endothelial activity worsen endothelial dysfunction and exercise intolerance in AF. The advantages of CV appear to be inversely related to the extent of the underlying oxidative injury.
Guazzi et al. (Sat,) conducted a observational in Atrial fibrillation (lone, or with hypertension, or with diabetes) (n=80). Cardioversion vs. Baseline (before cardioversion) and across patient groups was evaluated on Cardiopulmonary exercise, pulmonary, and endothelial function. Cardioversion improved peak workload (+18% vs +7%) and peak VO2 (+17% vs +12%) more in lone atrial fibrillation than in AF with hypertension, and was ineffective in AF with diabetes.