Key result
Long-term stroke mortality falls ~2% annually, but absolute burden and young ischemic stroke deaths rise.
Why the study?
Despite substantial declines in burden over time, stroke remains a public health threat in the Americas, prompting an assessment of its current magnitude, trends, and disparities by sex and age.
Observational
Effect estimate: AAPC -1.8% (95% CI -1.9 to -1.8)
p-value: p=<0.0001
Despite historical declines in age-standardized rates, stroke incidence and ischemic stroke mortality have alarmingly reversed to an upward trend among younger populations in the Americas since 2015.
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Alerts clinicians to rising ischemic stroke mortality in younger adults; leaves open drivers and targeted prevention research.
Martínez et al. (2025) conducted an observational in Stroke. Despite a long-term decline in age-standardized stroke mortality rates (AAPC -1.8%), the absolute burden increased, and ischemic stroke mortality among younger populations reversed to an upward trend from 2015 to 2021.