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To compare the effects of inhaled salbutamol versus epinephrine on transient tachypnea in newborns.

May 29, 2026

Inhaled Salbutamol Versus Epinephrine in Treatment of Transient Tachypnea of Newborn (TTN): A Randomized Control Trial

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To compare the effects of inhaled salbutamol versus epinephrine on transient tachypnea in newborns.
Prospective randomized control study at NICU from December 2021 to May 2022.
150 neonates divided into three groups: control, salbutamol, and epinephrine treatment.
Each treatment group received standard care with additional inhaled medication.
Salbutamol group had a significantly lower respiratory rate compared to control (p=0.002) and epinephrine group (p=0.005).
All groups showed increased PaO2 and decreased PaCO2 post-treatment, with significant changes (p<0.001).
Salbutamol group experienced shorter hospital stays compared to control (p=0.004).

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Randomized trial compares inhaled salbutamol and epinephrine effects on newborn respiratory distress, suggesting salbutamol is more effective.

Ali et al. (2024) studied this question.

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Randomized trial compares inhaled salbutamol and epinephrine effects on newborn respiratory distress, suggesting salbutamol is more effective.