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May 29, 2026Naunyn-Schmiedeberg s Archives of PharmacologyOpen Access

Neuroprotective effects of luteolin against aluminum-induced brain injury via chelation and antioxidant pathways

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Authors

ŞAŞeyma AydınAtatürk UniversityEDElif DalkılınçAtatürk UniversitySÖSelçuk ÖzdemirAtatürk University

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Implication

Randomized trial investigates luteolin's protective effects against aluminum neurotoxicity in rats, suggesting potential for public health utility.

Key Points

  • The study aims to evaluate the neuroprotective effects of luteolin against aluminum-induced brain injury.
  • Sprague-Dawley rats were administered AlCl3 (4.2 mg/kg, i.p.) alone or with luteolin (25 or 50 mg/kg, p.o.) for 30 days.
  • Behavioral performance was assessed using novel object recognition and open-field tests.
  • ICP-MS was used to measure brain aluminum levels and assess oxidative stress and neuroinflammation.
  • AlCl3 exposure significantly increased brain aluminum levels and induced oxidative stress, inflammation, and apoptosis.
  • Luteolin co-treatment produced Al–LUT complexes, leading to reduced oxidative stress and behavioral deficits.
  • Behavioral outcomes improved with luteolin treatment, indicating neuroprotective effects against aluminum toxicity.

Cite This Study

Aydın et al. (2026) studied this question.

synapsesocial.com/papers/6a192ee7fab5b468c4418265https://doi.org/10.1007/s00210-026-05459-7
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