Therapeutic Use of Cannabis: Knowledge and Acceptance among Citizens of Trujillo, Peru

<ns3:p>Background In Peru, the legalization of Cannabis was given in 2017 and approved in 2019; however, there are discrepancies in the knowledge of the therapeutic use of this plant, causing rejection in its application as an alternative medicine. Methods The research was of a basic type with a quantitative approach and a non-experimental design, with a cross-sectional and descriptive scope. Non-probabilistic sampling was applied, with 324 participants aged 18-60. Data were collected through a virtual questionnaire of closed questions (KR-20 = 0.825). Descriptive statistics were used (frequencies and percentages), and inferential analyses Spearman’s correlation, simple linear regression, Monte Carlo exact tests, and a two-step cluster analysis to identify acceptance profiles. Results Participants expressed a favorable perception of the potential benefits of medical cannabis. However, their knowledge of its therapeutic indications and dosage was limited. Inferential analyses revealed a significant positive association between knowledge and acceptance of the therapeutic use of cannabis. Knowledge emerged as a significant predictor of acceptance, although it explained only a limited proportion of its variability. Cluster analysis identified distinct acceptance profiles within the study population, showing adequate internal cohesion and separation, and highlighting knowledge as the most influential factor in cluster formation. Despite moderate acceptance of regular use under medical supervision, participants emphasized that cannabis use should be limited to prescriptions from specialized physicians and supported by scientific evidence. Conclusion Study participants demonstrate limited knowledge about medical cannabis, despite moderate acceptance of its regulated use. Knowledge plays an important, though not exclusive, role in shaping acceptance, underscoring the need for targeted educational strategies and evidence-based public health policies.</ns3:p>