What question did this study set out to answer?

May 29, 2026Journal of Clinical Oncology

Neoadjuvant fractionated stereotactic radiotherapy followed by surgical resection for brain metastases: A multicenter, single arm phase II trial (NEO-TACTICS).

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Authors

KMKoichi MitsuyaShizuoka Cancer Center TOTsuyoshi OnoeShizuoka Cancer Center HHHideyuki HaradaShizuoka Cancer Center

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Implication

Randomized trial evaluates local control and cognitive outcomes after neoadjuvant treatment for brain metastases, suggesting a promising new approach.

Key Points

This trial aims to evaluate the safety and efficacy of neoadjuvant fractionated stereotactic radiotherapy followed by surgical resection for brain metastases.
Phase II trial conducted across 14 centers with 57 enrolled patients.
Patients received neoadjuvant fractionated stereotactic radiotherapy (30-35 Gy in 5 fractions) targeting the index brain metastasis before surgical resection.
Primary endpoint was the 6-month cumulative incidence of local recurrence at the surgical site.
6-month cumulative incidence of local recurrence was 4.3% (95% CI: 0–10.1).
No leptomeningeal dissemination observed at 6 or 12 months.
Median overall survival rate was 86.3% (95% CI: 77.3-96.3) at 6 months.

Cite This Study

Mitsuya et al. (2026) studied this question.

synapsesocial.com/papers/6a192f1bfab5b468c44186cb https://doi.org/10.1200/jco.2026.44.16_suppl.2003

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Implication

Randomized trial evaluates local control and cognitive outcomes after neoadjuvant treatment for brain metastases, suggesting a promising new approach.

Neoadjuvant fractionated stereotactic radiotherapy followed by surgical resection for brain metastases: A multicenter, single arm phase II trial (NEO-TACTICS).

Discussion

Member takes

Implication

Key Points

Cite This Study

Neoadjuvant fractionated stereotactic radiotherapy followed by surgical resection for brain metastases: A multicenter, single arm phase II trial (NEO-TACTICS).

Discussion

Member takes

Implication

Key Points

Cite This Study

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