Exaggerated placental site reaction associated with complete hydatidiform mole: A rare case report

Exaggerated placental site reaction (EPSR) is a rare, benign trophoblastic proliferation characterised by excessive infiltration of placental trophoblasts into the endometrium and myometrium. It is most commonly observed following normal pregnancy or abortion but may also, albeit rarely, occur after molar or ectopic pregnancies. Histologically, EPSR must be carefully distinguished from malignant trophoblastic tumours, as it exhibits morphology and immunophenotypic features identical to the intermediate trophoblastic cells seen in these neoplasms. The present case describes a rare instance of EPSR associated with a complete mole in a 46-year-old patient, highlighting the clinical importance of accurate recognition and differentiation from malignant processes.