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Shows glibenclamide does not affect morphine's actions on the intestines, suggesting different mechanisms.
The effects of morphine on gastrointestinal transit and castor oil diarrhea were studied in rats. These were antagonised by naloxone but not by the ATP-dependent potassium channel blocker glibendamide. Glibenclamide also failed to antagonise the antidiarrhoeal action of the peripherally acting opioid, loperamide. This suggests that the intestinal actions of morphine unlike its analgesic action are probably not mediated via the glibenclamide - sensitive potassium channel.
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Sunita et al. (1994) studied this question.
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