What is the clinical evidence from this study?

Study design: Observational. Population: Blunt cardiac injury in severe trauma patients with sternum fracture (n=63). Intervention: NT pro-BNP and Cardiac Index monitoring vs. Non-blunt cardiac injury (Non-BCI) group. Primary outcome: Median NT pro-BNP on admission (pg/mL) (p=0.08).

What does this research mean for the field?

NT pro-BNP and cardiac index show no consistent correlation with ECG-based blunt cardiac injury diagnosis, whereas elevated lactate levels may serve as an adjunctive tool for early recognition. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 10, 2023BMC Cardiovascular DisordersOpen Access

Serum pro-B-type natriuretic peptide levels and cardiac index as adjunctive tools of blunt cardiac injury

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Key result

Elevated lactate, unlike NT-proBNP or cardiac index, is linked to blunt cardiac injury.

P=0.08
n=63

Why the study?

The utility of diagnostic tests for cardiac disease as adjunctive tools for blunt cardiac injury remains unclear.

Do NT-proBNP, cardiac index, and lactate levels improve the early diagnosis of blunt cardiac injury in severe trauma patients with sternum fractures?

Population

63 severe trauma patients aged 18 years or older with sternum fracture and ISS > 16

Comparison

BCI vs non-BCI

Design

Observational study

Follow-up

48 h after trauma

Authors

CBChae-Min BaeKyungpook National University Hospital JCJoon Yong ChoKyungpook National University Hospital HJHanna JungKyungpook National University Hospital

Discussion

Member takes

Implication

Lactate may aid early BCI recognition in sternal fracture trauma; leaves open NT-proBNP and cardiac index utility.

Study Design

Type

Observational (n=63)

Multicenter

Structured PICO

Do NT-proBNP, cardiac index, and lactate levels improve the early diagnosis of blunt cardiac injury in severe trauma patients with sternum fractures?

Population

63 severe trauma patients with sternum fracture, aged ≥18 years, with injury severity score (ISS) > 16 requiring intensive care. Median age 58 (non-BCI) and 60 (BCI), 72.7-80.0% male. Excluded patients with factors affecting NT-proBNP (e.g., intracranial hemorrhage, prior MI, CHF, renal/hepatic disease).

Intervention

Measurement of NT-proBNP, cardiac index (C.I) via pulse contour analysis, and lactate levels at admission, 24 hours (HD 2), and 48 hours (HD 3).

Comparator

Patients diagnosed with non-blunt cardiac injury (non-BCI) vs. blunt cardiac injury (BCI) based on the AAST Cardiac Injury Scale.

Outcome

Diagnostic competence of NT-proBNP, cardiac index, and lactate levels for blunt cardiac injury (BCI) compared to ECG-based diagnosis.surrogate

Main Result

Absolute Event Rate: 130% vs 125%

p-value: p=0.08

While NT-proBNP and cardiac index did not reliably correlate with ECG-based blunt cardiac injury diagnosis, elevated lactate levels may serve as a useful adjunctive tool for early recognition in severe trauma patients.

Limitations

Single-center retrospective study with a small number of patients
Lack of accurate gold standard diagnostic criteria for blunt cardiac injury
Postoperative results are highly influenced by other accompanying injuries
Investigated diagnostic adjuvant tools do not directly influence patient treatment or survival
No accurate diagnostic criteria for BCI (used AAST scale)
Postoperative results highly influenced by accompanying injuries
Investigated diagnostic adjuvant tools so it does not influence treatment or survival

Cite This Study

Bae et al. (2023) conducted an observational in Blunt cardiac injury in severe trauma patients with sternum fracture (n=63). NT pro-BNP and Cardiac Index monitoring vs. Non-blunt cardiac injury (Non-BCI) group was evaluated on Median NT pro-BNP on admission (pg/mL) (p=0.08). NT pro-BNP and cardiac index showed no consistent correlation with ECG-based blunt cardiac injury diagnosis, whereas lactate levels were significantly higher in patients with blunt cardiac injury.

synapsesocial.com/papers/6a193288a0353395e957ff8d https://doi.org/10.1186/s12872-022-02990-2

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February 10, 2023BMC Cardiovascular DisordersOpen Access

Serum pro-B-type natriuretic peptide levels and cardiac index as adjunctive tools of blunt cardiac injury

View Full Paper

Ask AI

Bookmark

Key result

Elevated lactate, unlike NT-proBNP or cardiac index, is linked to blunt cardiac injury.

P=0.08
n=63

Why the study?

The utility of diagnostic tests for cardiac disease as adjunctive tools for blunt cardiac injury remains unclear.

Do NT-proBNP, cardiac index, and lactate levels improve the early diagnosis of blunt cardiac injury in severe trauma patients with sternum fractures?

Population

63 severe trauma patients aged 18 years or older with sternum fracture and ISS > 16

Comparison

BCI vs non-BCI

Design

Observational study

Follow-up

48 h after trauma

Authors

CBChae-Min BaeKyungpook National University Hospital JCJoon Yong ChoKyungpook National University Hospital HJHanna JungKyungpook National University Hospital

Discussion

Member takes

Implication

Lactate may aid early BCI recognition in sternal fracture trauma; leaves open NT-proBNP and cardiac index utility.

Study Design

Type

Observational (n=63)

Multicenter

Structured PICO

Do NT-proBNP, cardiac index, and lactate levels improve the early diagnosis of blunt cardiac injury in severe trauma patients with sternum fractures?

Population

Intervention

Measurement of NT-proBNP, cardiac index (C.I) via pulse contour analysis, and lactate levels at admission, 24 hours (HD 2), and 48 hours (HD 3).

Comparator

Patients diagnosed with non-blunt cardiac injury (non-BCI) vs. blunt cardiac injury (BCI) based on the AAST Cardiac Injury Scale.

Outcome

Diagnostic competence of NT-proBNP, cardiac index, and lactate levels for blunt cardiac injury (BCI) compared to ECG-based diagnosis.surrogate

Main Result

Absolute Event Rate: 130% vs 125%

p-value: p=0.08

Limitations

Single-center retrospective study with a small number of patients
Lack of accurate gold standard diagnostic criteria for blunt cardiac injury
Postoperative results are highly influenced by other accompanying injuries
Investigated diagnostic adjuvant tools do not directly influence patient treatment or survival
No accurate diagnostic criteria for BCI (used AAST scale)
Postoperative results highly influenced by accompanying injuries
Investigated diagnostic adjuvant tools so it does not influence treatment or survival

Cite This Study

synapsesocial.com/papers/6a193288a0353395e957ff8d https://doi.org/10.1186/s12872-022-02990-2

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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