Population
Single myocytes isolated from guinea-pig or bovine ventricles
Comparison
Anemonia sulcata toxin at concentrations of 2-40… vs Control conditions (absence of ATX II)
Design
Preclinical
Authors
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May inform arrhythmia mechanisms in animal models; leaves open translation to human ventricular electrophysiology.
ATX II prolongs action potential duration and induces a TTX-sensitive inward current in mammalian ventricular myocytes.
Isenberg et al. (1984) studied this question.
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