Key result
Whole genome expression profiling of myocardial biopsies from dilated cardiomyopathy patients compared to healthy donors identified 364 differentially expressed transcripts (FDR <0.001).
Why the study?
What are the global gene expression changes accompanying human dilated cardiomyopathy?
Population
Myocardial biopsies from 10 patients with dilated cardiomyopathy with moderate heart failure, and tissue…
Comparison
Whole genome expression profiling using UniGene… vs Tissue samples from 4 non-failing, healthy donors
Design
Preclinical
Authors
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Transcriptomic changes in human DCM biopsies are hypothesis-generating; leaves open causal roles and therapeutic relevance pending functional validation.
Observational (n=14)
What are the global gene expression changes accompanying human dilated cardiomyopathy?
p-value: p=<0.001
This genome-wide expression profiling of human DCM biopsies identifies 364 differentially expressed transcripts, highlighting the role of intracellular signaling and muscle contraction genes in the pathophysiology of the disease.
Grzeskowiak et al. (2003) conducted an observational in Dilated cardiomyopathy (n=14). Whole genome expression profiling vs. Non-failing, healthy donors was evaluated on Differentially expressed transcripts (p=<0.001). Whole genome expression profiling of myocardial biopsies from dilated cardiomyopathy patients compared to healthy donors identified 364 differentially expressed transcripts (FDR <0.001).
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