Key result
Self-expanding TAVI shows comparable long-term mortality and SVD to balloon-expandable valves.
Why the study?
Long-term comparative clinical outcomes beyond 5 years between self-expanding and balloon-expandable valves in patients undergoing TAVI remained to be evaluated.
Does TAVI with self-expanding valves compared to balloon-expandable valves improve long-term clinical outcomes in patients with severe aortic stenosis?
Observational (n=74)
Does TAVI with self-expanding valves compared to balloon-expandable valves improve long-term clinical outcomes in patients with severe aortic stenosis?
Self-expanding and balloon-expandable valves demonstrate comparable long-term clinical outcomes and structural valve deterioration risk at a median follow-up of 6.8 years post-TAVI.
Answers are grounded in this paper and cite their sources.
Supports comparable long-term TAVI valve durability; hypothesis-generating and should not yet change practice.
Background This study aimed to compare long-term clinical outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) with self-expanding (SEV) valve versus balloon-expandable valve (BEV), with a minimum follow-up period of 5 years. Materials and Methods Utilizing a prospectively maintained database, this observational study identified patients who underwent TAVI using either SEV or BEV for severe aortic stenosis and were followed for at least 5 years. Clinical outcomes encompassed both 30-day post-TAVI outcomes and long-term outcomes, including all-cause mortality, cardiovascular mortality, structural valve deterioration (SVD), heart failure–related hospitalization, bioprosthetic valve failure, and valve-related hospitalization and complications. Results A total of 74 patients were included in this study, with 64 patients in the SEV group and 10 patients in the BEV group. The median follow-up duration was 6.8 years, ranging from 5.0 to 10.2 years. Throughout the post-TAVI period, the SEV group consistently demonstrated a lower mean pressure gradient than the BEV group. No significant differences were observed between the 2 groups in terms of short-term or long-term outcomes. Within the study, 4 patients encountered moderate or severe SVD and 1 experienced thrombosis, and no cases of bioprosthetic valve failure or endocarditis were observed. Conclusions This study revealed that SEV and BEV demonstrated comparable long-term outcomes in patients undergoing TAVI, including all-cause and cardiovascular mortality, as well as the risk of SVD.
No takes yet. Share an insight, caveat, or question.
Hoo et al. (2024) conducted an observational in Severe aortic stenosis (n=74). Self-expanding valves (SEV) vs. Balloon-expandable valves (BEV) was evaluated on 30-day and long-term clinical outcomes including all-cause mortality, cardiovascular mortality, structural valve deterioration, heart failure-related hospitalization, bioprosthetic valve failure, and valve-related hospitalization and complications. TAVI with self-expanding valves (n=64) demonstrated comparable long-term outcomes to balloon-expandable valves (n=10) over a median 6.8 years, with no significant differences in mortality or SVD.
Synapse has enriched 10 related papers. Consider them for comparative context: