Key result
In patients with chronic kidney disease, stage 3 CKD significantly increased the risk of venous thromboembolism (OR 2.28), alongside other factors including female gender, heart failure, and atrial fibrillation.
Why the study?
To identify the risk factors contributing to venous thromboembolism in patients with chronic kidney disease.
What are the clinical risk factors that increase the risk of venous thromboembolism in patients with chronic kidney disease?
Meta-Analysis (n=1,619,782)
What are the clinical risk factors that increase the risk of venous thromboembolism in patients with chronic kidney disease?
In patients with chronic kidney disease, advanced renal dysfunction, female sex, and comorbidities such as atrial fibrillation, heart failure, coronary artery disease, and systemic lupus erythematosus significantly increase the risk of venous thromboembolism.
PURPOSE: The objective of this study was to conduct a meta-analysis and systematic review to identify the risk factors contributing to thromboembolism (VTE) in chronic kidney disease (CKD) patients. METHODS: PubMed, Cochrane Library, Web of Science, and Embase databases were searched from inception to October 2024. Cohort, case-control, and cross-sectional studies examining risk factors for VTE in CKD were included. Quality assessment and data extraction were conducted. CONCLUSIONS: Different CKD stages, female, CHF, AF, CAD, and SLE emerge as significant risk factors for VTE in CKD patients. Additionally, VTE risk can be influenced by dialysis modality and other factors. Physicians should comprehensively assess the risk of VTE in patients with CKD.
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Zhan et al. (2024) conducted a meta-analysis in Chronic kidney disease (n=1,619,782). CKD stage 3 vs. Lower CKD stages was evaluated on Venous thromboembolism (VTE) (OR 2.28, 95% CI 1.76-2.95, p=<0.01). In patients with chronic kidney disease, stage 3 CKD significantly increased the risk of venous thromboembolism (OR 2.28), alongside other factors including female gender, heart failure, and atrial fibrillation.
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