Key result
Impaired renal function (eGFR <60 mL/min) significantly increased the risk of thromboembolic events in patients with nonvalvular atrial fibrillation (RR 1.62; 95% CI 1.40-1.87; P<0.001).
Why the study?
Does impaired renal function (eGFR <60 mL/min) increase the risk of thromboembolic events in patients with nonvalvular atrial fibrillation?
Population
18 studies involving 538,479 patients with nonvalvular atrial fibrillation
Comparison
Estimated glomerular filtration rate <60 mL/min vs Estimated glomerular filtration rate ≥60 mL/min
Design
Meta-analysis
Authors
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eGFR <60 mL/min elevates thromboembolic risk in AF; supports refined stratification but leaves optimal integration open for validation.
Meta-Analysis (n=538,479)
Does impaired renal function (eGFR <60 mL/min) increase the risk of thromboembolic events in patients with nonvalvular atrial fibrillation?
Relative Risk: 1.62 (95% CI 1.4–1.87)
p-value: p=<0.001
Impaired renal function (eGFR <60 mL/min) is an independent predictor of stroke or systemic embolism in patients with nonvalvular AF, and its inclusion may improve stroke risk stratification.
Zeng et al. (2014) conducted a meta-analysis in Nonvalvular atrial fibrillation (n=538,479). Estimated glomerular filtration rate <60 mL/min vs. Estimated glomerular filtration rate ≥60 mL/min was evaluated on Thromboembolic events (RR 1.62, 95% CI 1.40-1.87, p=<0.001). Impaired renal function (eGFR <60 mL/min) significantly increased the risk of thromboembolic events in patients with nonvalvular atrial fibrillation (RR 1.62; 95% CI 1.40-1.87; P<0.001).
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