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March 2, 2009Circulation450 citationsOpen Access

Impact of Proteinuria and Glomerular Filtration Rate on Risk of Thromboembolism in Atrial Fibrillation

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AGAlan S. GoMFMargaret C. FangNUNatalia Udaltsova

Key Points

  • This research examines how proteinuria and glomerular filtration rate affect thromboembolism risk in patients with atrial fibrillation.
  • Analyzed the interplay between chronic kidney disease and thromboembolism in atrial fibrillation.

Structured PICO

Does assessing proteinuria and glomerular filtration rate improve risk stratification for thromboembolism in patients with atrial fibrillation?

P
Population
Patients with atrial fibrillation
O
Outcome
Thromboembolismhard clinical

Assessing kidney function and proteinuria may improve risk stratification for thromboembolism and guide antithrombotic therapy decisions in patients with atrial fibrillation.

Abstract

Chronic kidney disease increases the risk of thromboembolism in AF independently of other risk factors. Knowing the level of kidney function and the presence of proteinuria may improve risk stratification for decision making about the use of antithrombotic therapy for stroke prevention in AF.

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Cite This Study

Go et al. (2009) studied this question.

synapsesocial.com/papers/69d56dde75589c71d767d162https://doi.org/10.1161/circulationaha.108.816082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Levels of Tissue Plasminogen Activator Antigen and Factor VIII Activity in Nonvalvular Atrial Fibrillation: Relation to Predictors of Thromboembolism2001 · 36 citations
  2. 2Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.1991 · 7,522 citations
  3. 3Increased Arterial Stiffness in Young Adults with End-Stage Renal Disease since Childhood2002 · 98 citations
  4. 4Cardiac sources of embolism and cerebral infarction—clinical consequences and vascular concomitants1991 · 229 citations
  5. 5Risk Factors for Stroke and Efficacy of Antithrombotic Therapy in Atrial Fibrillation1994 · 2,079 citations