Key result
Atrial fibrillation had no independent impact on 90-day stroke outcome (OR 0.93; 95% CI 0.84-1.03; P=0.409), and thrombolysis improved outcomes equally regardless of AF status.
Why the study?
Does thrombolysis improve 90-day modified Rankin Scale scores in acute stroke patients regardless of the presence of atrial fibrillation?
Observational (n=7,091)
Yes
Does thrombolysis improve 90-day modified Rankin Scale scores in acute stroke patients regardless of the presence of atrial fibrillation?
Effect estimate: OR 0.93 (95% CI 0.84-1.03)
p-value: p=0.409
Thrombolysis provides a similar magnitude of benefit in acute stroke patients regardless of whether they have a history of atrial fibrillation.
Supports thrombolysis in acute stroke regardless of AF; leaves open randomized confirmation.
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Frank et al. (2012) conducted an observational in Acute stroke (n=7,091). Atrial fibrillation vs. No atrial fibrillation was evaluated on improved modified Rankin Scale score at 90 days (OR 0.93, 95% CI 0.84-1.03, p=0.409). Atrial fibrillation had no independent impact on 90-day stroke outcome (OR 0.93; 95% CI 0.84-1.03; P=0.409), and thrombolysis improved outcomes equally regardless of AF status.
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