What question did this study set out to answer?

To evaluate whether cardiac angiotensin converting enzyme (ACE) expression and activity are upregulated during hypoxia-induced right ventricular hypertrophy.

May 1, 1997Cardiovascular Research

Right ventricular angiotensin converting enzyme activity and expression is increased during hypoxic pulmonary hypertension

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Why the study?

Does chronic hypoxia alter local cardiac ACE activity and expression in rats?

Population

Normoxic rats and rats exposed to chronic hypoxia for 8 and 14 days

Comparison

Chronic hypoxia for 8 and 14 days vs Normoxia (control)

Design

Preclinical

Follow-up

14 days

Authors

NMNicholas W. MorrellVascular Medicine

Discussion

Member takes

Implication

Hypothesis-generating for local RV ACE in hypoxic hypertrophy; leaves open clinical translation or targeted inhibition in pulmonary hypertension.

Key Points

To evaluate whether cardiac angiotensin converting enzyme (ACE) expression and activity are upregulated during hypoxia-induced right ventricular hypertrophy.
Measured membrane-bound ACE activity in the right ventricle and left ventricle plus septum in normoxic rats and rats exposed to chronic hypoxia for 8 and 14 days.
Assessed cardiac ACE localization using immunohistochemistry with the monoclonal antibody 9B9.
Right ventricular ACE activity increased 2.6-fold at day 8 and 3.4-fold at day 14 of chronic hypoxia, correlating positively with the degree of right ventricular hypertrophy (r = 0.83, P < 0.001).
Left ventricular plus septal ACE activity decreased by approximately 40% and 60% at 8 and 14 days of hypoxia, respectively, relative to controls.
Immunohistochemistry showed increased ACE expression in right ventricular epicardium and fibrotic regions, but reduced ACE-expressing capillaries in the left ventricular free wall.

Structured PICO

Does chronic hypoxia alter local cardiac ACE activity and expression in rats?

Population

Normoxic rats and rats exposed to chronic hypoxia for 8 and 14 days

Intervention

Chronic hypoxia for 8 and 14 days

Comparator

Normoxia (control)

Outcome

Membrane-bound right ventricular and left ventricular plus septal ACE activity and local cardiac ACE expressionsurrogate

Chronic hypoxia differentially affects ventricular ACE activity, upregulating it in the right ventricle where it correlates with hypertrophy, suggesting a role in the pathogenesis of hypoxic pulmonary hypertension-induced right ventricular hypertrophy.

Cite This Study

Nicholas W. Morrell (1997) studied this question.

synapsesocial.com/papers/6a194f5afa25ab5db6d95a71 https://doi.org/10.1016/s0008-6363(97)00049-7

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Implication

Hypothesis-generating for local RV ACE in hypoxic hypertrophy; leaves open clinical translation or targeted inhibition in pulmonary hypertension.

Right ventricular angiotensin converting enzyme activity and expression is increased during hypoxic pulmonary hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Right ventricular angiotensin converting enzyme activity and expression is increased during hypoxic pulmonary hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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