What does this research mean for the field?

The clinical interpretation and prognostic impact of a Coronary Artery Calcium (CAC) score depends significantly on an individual's pretest conventional cardiovascular risk factors, as the identical CAC score can either increase or decrease estimated risk depending on the expected value. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

July 25, 2013CirculationOpen Access

Multivariable models using conventional risk factors predicted the presence of CAC (C statistic=0.789) and degree of elevation (16% of variation explained).

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Why the study?

Does interpreting the coronary artery calcium score in the context of expected scores based on conventional risk factors alter CHD risk estimation in adults?

Population

6,757 black, Chinese, Hispanic, and white men and women aged 45 to 84 years in the Multi-Ethnic Study of…

Design

Cohort

Authors

MPMark J. Pletcher CSChristopher T. Sibley MPMichael Pignone

Discussion

Member takes

Overview

Conventional risk factors moderately predict CAC; leaves open whether deviation from expected refines CHD risk estimates in observational cohorts.

Structured PICO

Does interpreting the coronary artery calcium score in the context of expected scores based on conventional risk factors alter CHD risk estimation in adults?

Population

6,757 black, Chinese, Hispanic, and white men and women aged 45 to 84 years in the Multi-Ethnic Study of Atherosclerosis (MESA)

Intervention

Coronary artery calcium (CAC) score interpretation based on expected score from conventional risk factors

Outcome

Prediction of the presence of CAC and degree of elevationsurrogate

Interpreting an individual's CAC score relative to their expected score based on conventional risk factors can significantly alter their estimated CHD risk, aiding clinical decision-making.

Cite This Study

Pletcher et al. (2013) studied this question.

synapsesocial.com/papers/6a196328214a3f02e0d95c50 https://doi.org/10.1161/circulationaha.113.002598

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July 25, 2013CirculationOpen Access

Multivariable models using conventional risk factors predicted the presence of CAC (C statistic=0.789) and degree of elevation (16% of variation explained).

View Full Paper

Ask AI

Bookmark

Why the study?

Does interpreting the coronary artery calcium score in the context of expected scores based on conventional risk factors alter CHD risk estimation in adults?

Population

6,757 black, Chinese, Hispanic, and white men and women aged 45 to 84 years in the Multi-Ethnic Study of…

Design

Cohort

Authors

MPMark J. Pletcher CSChristopher T. Sibley MPMichael Pignone

Discussion

Member takes

Overview

Conventional risk factors moderately predict CAC; leaves open whether deviation from expected refines CHD risk estimates in observational cohorts.

Structured PICO

Does interpreting the coronary artery calcium score in the context of expected scores based on conventional risk factors alter CHD risk estimation in adults?

Population

6,757 black, Chinese, Hispanic, and white men and women aged 45 to 84 years in the Multi-Ethnic Study of Atherosclerosis (MESA)

Intervention

Coronary artery calcium (CAC) score interpretation based on expected score from conventional risk factors

Outcome

Prediction of the presence of CAC and degree of elevationsurrogate

Interpreting an individual's CAC score relative to their expected score based on conventional risk factors can significantly alter their estimated CHD risk, aiding clinical decision-making.

Cite This Study

Pletcher et al. (2013) studied this question.

synapsesocial.com/papers/6a196328214a3f02e0d95c50 https://doi.org/10.1161/circulationaha.113.002598

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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