Population
Muscle homogenate, myofibrils, and isolated troponin complex (preclinical model)
Comparison
Monoclonal antibody against the conserved COOH… vs Absence of Ca2+ / baseline conformation
Design
Preclinical
Authors
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May inform troponin-related cardiomyopathy mechanisms; extends animal biochemical data but leaves open human translation.
The highly conserved COOH terminus of troponin I forms an essential allosteric domain that undergoes conformational changes during Ca2+ activation of muscle contraction.
Jin et al. (2001) studied this question.
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