Comparison of Electrocardiographic Biomarkers for Differentiating Drug‐Induced Single vs. Multiple Cardiac Ion Channel Block

Figures

• 

  Figure 1. TSAT protocol. Scatter plot of multiple logistic regression results. Model used logit ~1 + JTpc (measured from the J point to the peak of the T‐wave, corrected for heart rate) + corrected QT Fridericia's formula (QTcF). FP, false positive; FN, false negative. All values in milliseconds.

• 

  Figure 2. BTBT protocol. Scatter plot of multiple logistic regression results. Model used logit ~1 + JTpc (measured from the J point to the peak of the T‐wave, corrected for heart rate) + corrected QT Fridericia's formula (QTcF). FP, false positive; FN, false negative. All values in milliseconds.

• 

  Figure 3. BTB5 protocol. Scatter plot of multiple logistic regression results. Model used logit ~1 + JTpc (measured from the J point to the peak of the T‐wave, corrected for heart rate) + corrected QT Fridericia's formula (QTcF). O, low‐risk measure; FN, false negative. All values in milliseconds.

• 

  Figure 4. BTB30 protocol. Scatter plot of multiple logistic regression results. Model used logit ~1 + JTpc (measured from the J point to the peak of the T‐wave, corrected for heart rate) + corrected QT Fridericia's formula (QTcF). FP, false positive; FN, false negative. All values in milliseconds.

• 

  Figure 5. Scatter plots of QT vs. RR during 5‐minute time points (blue), traditional interval measurements at prespecified time points (black), beat‐to‐beat 5 (red) for the following time points: baseline, placebo, and ranolazine at 2.5 hours postdose.