Key result
Pure hERG block equally prolongs early and late repolarization while added inward block shortens early repolarization.
Why the study?
Can the electrocardiogram differentiate the effects of pure hERG block versus multichannel drug block by separate analysis of early and late repolarization in human subjects?
Population
22 subjects
Comparison
Dofetilide, quinidine, ranolazine, and verapamil vs Comparison among the different drugs
Design
RCT, randomized
Authors
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Separate early/late repolarization analysis on ECG may refine drug proarrhythmia risk assessment; extends multichannel block evaluation beyond QT interval.
RCT (n=22)
Randomized
Can the electrocardiogram differentiate the effects of pure hERG block versus multichannel drug block by separate analysis of early and late repolarization in human subjects?
Separate analysis of early and late repolarization on the ECG can differentiate pure hERG block from multichannel block, potentially improving the assessment of drug-induced arrhythmia risk.
Johannesen et al. (2014) conducted an RCT in Drug-induced multichannel block (n=22). Dofetilide, quinidine, ranolazine, and verapamil was evaluated on Early repolarization (global J-Tpeak) and late repolarization (global Tpeak-Tend). Pure hERG potassium channel block equally prolonged early and late repolarization, whereas additional inward current block preferentially shortened early repolarization.
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