Key result
Dofetilide and quinidine (P<0.001), as well as ranolazine (P<0.01), caused significant T wave morphology changes, whereas strong calcium and hERG block with verapamil did not.
Why the study?
Does administration of multichannel blocking drugs (quinidine, ranolazine, verapamil) prevent T wave morphology changes compared to pure hERG block (dofetilide) in healthy subjects?
Population
22 healthy subjects
Comparison
Single dose of dofetilide, quinidine… vs Placebo (in a 5-period cross-over design)
Design
RCT, Randomized cross-over, Placebo-controlled
Follow-up
15 time-points post-dose
Authors
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Multichannel block with quinidine or ranolazine fails to prevent T wave changes; confirms these track hERG block magnitude independent of calcium effects.
RCT (n=22)
Placebo-controlled
Cross-over
Does administration of multichannel blocking drugs (quinidine, ranolazine, verapamil) prevent T wave morphology changes compared to pure hERG block (dofetilide) in healthy subjects?
p-value: p=<0.001
Multichannel block with quinidine and ranolazine does not prevent T wave morphology changes compared to pure hERG block, indicating that T wave morphology changes are directly related to the amount of hERG block.
Vicente et al. (2015) conducted an RCT in Healthy subjects (n=22). Dofetilide, quinidine, ranolazine, and verapamil vs. Placebo was evaluated on T wave morphology changes (p=<0.001). Dofetilide and quinidine (P<0.001), as well as ranolazine (P<0.01), caused significant T wave morphology changes, whereas strong calcium and hERG block with verapamil did not.
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