What question did this study set out to answer?

To evaluate the ultrastructural alterations occurring in axons, dendrites, and synaptic contacts within and surrounding senile plaques in Alzheimer's presenile dementia.

January 1, 1967Journal of Neuropathology & Experimental Neurology

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia*†

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To evaluate the ultrastructural alterations occurring in axons, dendrites, and synaptic contacts within and surrounding senile plaques in Alzheimer's presenile dementia.
Ultrastructural examination of cerebral cortical biopsy specimens from patients diagnosed with Alzheimer's presenile dementia.
Electron microscopic characterization of the fine structure of senile plaque cores, surrounding neurites, and pre- and post-synaptic terminals.
Confirmed that senile plaques feature an amyloid-like fibrillar core surrounded by abnormal cytoplasmic processes containing fibrils, multilamellar bodies, mitochondria, and dense bodies.
Identified previously unrecorded pathological changes in axons, dendrites, and both pre- and post-synaptic endings within and around senile plaques, indicating substantial synaptic degeneration.

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Implication

Electron microscopic study uncovers pre- and postsynaptic alterations within senile plaques in Alzheimer's dementia, highlighting synaptic disruption as a driver of memory impairment.

Cite This Study

Gonatas et al. (1967) studied this question.

synapsesocial.com/papers/6a19646cfa25ab5db6d97429 https://doi.org/10.1097/00005072-196701000-00003

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Implication

Electron microscopic study uncovers pre- and postsynaptic alterations within senile plaques in Alzheimer's dementia, highlighting synaptic disruption as a driver of memory impairment.

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia*†

Key Points

Discussion

Implication

Cite This Study

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia*†

Key Points

Discussion

Implication

Cite This Study

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