What does this research mean for the field?

Atrial natriuretic polypeptide (ANP) expression is augmented in dilated human ventricles regardless of the cause of dilatation, serving as a compensatory mechanism against decompensation in response to reduced contractility and excess wall stress. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1989Circulation

Ventricular expression of atrial natriuretic polypeptide and its relations with hemodynamics and histology in dilated human hearts. Immunohistochemical study of the endomyocardial biopsy specimens.

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Population

49 patients with cardiac dilatation due to dilated cardiomyopathy, postmyocarditis, or volume overload, and…

Design

Cross-sectional

Authors

GTG. TakemuraAsahi University HFHisayoshi FujiwaraHeart Failure / Cardiomyopathy KHK. HorikeKyoto University

Discussion

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Implication

Supports ANP as compensatory in dilated ventricles; cross-sectional data leave therapeutic implications open.

Structured PICO

Population

49 patients with cardiac dilatation due to dilated cardiomyopathy (n=21), postmyocarditis (n=18), or volume overload (n=5), and subjects with no dilatation as controls (n=5).

Outcome

Frequency of ANP-present myocytes in biventricular endomyocardial biopsy specimenssurrogate

ANP expression is augmented in dilated human ventricles as a compensatory mechanism responding to reduced contractility and increased wall stress.

Cite This Study

Takemura et al. (1989) studied this question.

synapsesocial.com/papers/6a19674aff42a97fac581eb3 https://doi.org/10.1161/01.cir.80.5.1137

Topics

Myocarditis

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Ventricular expression of atrial natriuretic polypeptide and its relations with hemodynamics and histology in dilated human hearts. Immunohistochemical study of the endomyocardial biopsy specimens.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Ventricular expression of atrial natriuretic polypeptide and its relations with hemodynamics and histology in dilated human hearts. Immunohistochemical study of the endomyocardial biopsy specimens.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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