What does this research mean for the field?

Herculin is a fourth member of the MyoD family of myogenic regulatory genes that induces myogenesis and is the most highly expressed myogenic regulator in adult skeletal muscle. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

February 1, 1990Proceedings of the National Academy of SciencesOpen Access

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

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Population

Murine NIH 3T3 and C3H/10T1/2 fibroblasts, and adult mice tissues

Design

Preclinical

Authors

JMJeffrey H. MinerWashington University in St. Louis BWB WoldCalifornia Institute of Technology

Discussion

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Implication

Identifies herculin as a novel murine myogenic factor; leaves open its role in human muscle maintenance or regeneration.

Structured PICO

Population

Murine NIH 3T3 and C3H/10T1/2 fibroblasts, and adult mice tissues

Intervention

Transfection and expression of the herculin gene under the control of the simian virus 40 early promoter

Outcome

Myogenic conversion of fibroblasts and tissue-specific expression levels in adult micesurrogate

The identification of herculin reveals a novel, highly expressed myogenic regulatory gene that can induce myogenesis and likely plays a key role in adult skeletal muscle maintenance.

Cite This Study

Miner et al. (1990) studied this question.

synapsesocial.com/papers/6a196753fa25ab5db6d976aa https://doi.org/10.1073/pnas.87.3.1089

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Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider