Why the study?
Risks of adverse birth outcomes in women exposed to varenicline during pregnancy were examined.
Does maternal varenicline use during pregnancy increase the risk of major congenital malformations or other adverse birth outcomes in infants?
Population
885 185 live-born and stillborn infants in Denmark and Sweden
Comparison
In utero varenicline exposure vs maternal smoking exposure vs unexposed reference
Design
Population-based cohort study
Follow-up
Birth to the first year of life
Authors
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No apparent malformation risk increase with varenicline; observational data leaves open need for confirmatory studies.
Does maternal varenicline use during pregnancy increase the risk of major congenital malformations or other adverse birth outcomes in infants?
Maternal use of varenicline during pregnancy does not appear to increase the risk of major congenital malformations or other adverse birth outcomes compared to maternal smoking.
Pedersen et al. (2019) studied this question.
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